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Dr. Bhabatosh Banik

Dr. Bhabatosh Banik

Assistant Professor

Ph.D. : Indian Institute of Science (IISc), Bangalore

Research Interests:

Platinum(IV)-based combination chemotherapeutics, Metal complexes as alternatives to Cisplatin, Nanoparticle mediated drug delivery, Immunomodulatory agents for cancer immunotherapy, Nanozymes, Anti-cardiovascular diagnostics and therapeutics.
Joined the University in May 12, 2021

Phone: 9101785405
Email: bhabatosh.banik@cottonuniversity.ac.in

Vidwan Profile
About Teaching Research Paper Publications Students Awards Patents Other Informations

About

Dr. Bhabatosh Banik spent his early days of school in the villages and towns of Arunachal Pradesh, post which he moved to Guwahati to pursue his bachelors degree. He obtained his B.Sc. degree from “AryaVidyapeeth College, Guwahati” and his M.Sc. degree with Inorganic Chemistry specialization from “Gauhati University, Guwahati”. He then joined the group of Prof. Akhil R. Chakravarty at the Inorganic and Physical Chemistry (IPC) department, Indian Institute of Science (IISc), for his Ph.D. degree. He had earned his Ph.D. degree in 2014, following which he moved to “Nanotherapeutics Research Laboratory” of Dr. Shanta Dhar at University of Georgia, USA. Later, he had moved with the laboratory to University of Miami, USA and worked there as a Postdoctoral Research Associate till 2017. In October 2017 he had joined the Department of Chemistry, Gauhati University, as a DST-INSPIRE Faculty and worked there till May 2021 before joining Cotton University. His research interests deal with the design and development of metal complexes and nano-formulations for diagnostic and therapeutic applications of cancer and cardiovascular diseases (CVDs).

Teaching

Inorganic Chemistry: M.Sc. second semester, M.Sc. fourth semester, B.Sc. fourth semester, H.S. second year

Research Projects

slno Name of the Project Name of the Principal Investigator Name of the Copi Name of the Funding agency Type (Government/Non-Government) Year Funds sanctioned (INR in lakhs) Duration of the project
1 Chemodynamic Immunotherapy: Employing ROS generating nanoparticles as immunomodulators to reprogram tumor-associated macrophages (TAMs) for cancer therapy
Status: Ongoing		 Dr. Bhabatosh Banik Department of Science (DST), India Government 2022 Rs. 34,75,560 3 years
2 Designing Platinum(IV)-based combination therapeutics by conjugating glycolysis inhibitors to Cisplatin
Status: Ongoing		 Dr. Bhabatosh Banik Dr. Anindita Chakraborty UGC-DAE Government 2022 Rs. 1,35,000 3 years
3 Stimuli-responsive nano-constructs for targeted delivery, site-selective release and activation of combination drugs
Status: Ongoing		 Dr. Bhabatosh Banik Department of Science (DST), India (under DST-INSPIRE Faculty Scheme) Government 2017 35,00,000 5 years

Research paper publications

2023

1. Bhabatosh Banik*, Akash Ashokan, Joshua Choi, Bapurao Surnar and Shanta Dhar*, Platin-C Nanoparticles: A Recipe for the Delivery of Curcumin-Cisplatin Combination Chemotherapeutics to Mitochondria, Dalton Transactions, vol. 52, 3575-3585, 2023 10.1039/D2DT03149C

Research paper publications till 2021

Publication from Postdoctoral Research

  1. Banik, B.; Surnar, B.; Askins, B. W.; Banerjee, M. and Dhar, S. (2020) “Dual Targeted Synthetic Nanoparticle for Cardiovascular Diseases”ACS Appl. Mater. Interfaces, 12(6), 6852-6862.
  2. Surnar, B.‡; Basu, U.‡;Banik, B.; Ahmad, A.; Marples, B.; Kolishetti, N. and Dhar, S. (2018) “Nanotechnology-mediated crossing of two impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection” Proc. Natl. Acad. Sci. USA, 115 (52), E12333-E12342. ‡Authors with equal contributions.
  3. Banik, B.‡; Wen, R.‡; Marrache, S.‡; Kumar, A.; Kolishetti, N.; Howerth, E. W.; and Dhar, S. (2018) “Core Hydrophobicity Tuning of a Self-Assembled Particle Results in Efficient Lipid Reduction and Favorable Organ Distribution” Nanoscale, 10, 366-377. ‡Authors with equal contributions.
  4. Banik, B.; and Dhar, S. (2017) “Centrifugation Free Magnetic Isolation of Functional Mitochondria Using Paramagnetic Iron Oxide Nanoparticles” Current Protocols in Cell Biology, 76, 25.4.1-25.4.20, DOI: 10.1002/cpcb.26.
  5. Banik, B.;Askins, B. W. and Dhar, S. (2016) “Mito-magneto: A tool for nanoparticle mediated isolation of mitochondria” Nanoscale, 8, 19581-19591.
  6. Basu, U.; Banik, B.; Wen, R.; Pathak, R. K.; and Dhar, S. (2016) “The Platin-X series: activation, targeting and delivery” Dalton Trans., 45, 12992-13004.
  7. Wen, R.; Banik, B.; Pathak, R. K.; Kumar, A.; Kolishetti, N. and Dhar. S. (2016)“Nanotechnology inspired tools for mitochondria dysfunction related diseases” Adv. Drug Deliv. Rev., 99 (Part A), 52-69.
  8. Kalathil, A. A.‡; Kumar, A.‡; Banik, B.‡; Ruiter, T. A.; Pathak, R. K. and Dhar. S. (2016)“New formulation of old aspirin for better delivery” Chem. Commun., 52, 140-143. ‡ Authors with equal contributions.

Publications from PhD

  1. Kumar, A.; Pant, I.; Dixit, A.; Banerjee, S.;Banik. B.; Saha, R.; Kondaiah, P.; Chakravarty, A. R.(2017) “Terpyridyloxovanadium(IV) complexes for DNA crosslinking and mito-targeted photocytotoxicity” J. Inorg. Biochem., 174, 45-54.
  2. Garai, A.; Pant, I.; Banerjee, S.; Banik. B.; Kondaiah, P.; Chakravarty, A. R. (2016) "Photorelease and Cellular Delivery of Mitocurcumin from Its Cytotoxic Cobalt(III) Complex in Visible Light" Inorg. Chem., 55 (12), 6027-6035.
  3. Somyajit, K. ‡; Banik, B. ‡; Saxena, S.; Babu S.; Hande, M. P.; Chakravarty, A. R.; Nagaraju, G. (2016)"Trans-dichlorooxovandium(IV) complex as a novel photoinducible DNA interstrand cross-linker for cancer therapy"Carcinogenesis, 37 (2), 145-156.‡ Authors with equal contributions.
  4. Banik, B.; Somyajit, K.; Nagaraju, G.; Chakravarty, A. R. (2014)“Oxovanadium(IV) catecholates of terpyridine bases for cellular imaging and photocytotoxicity in red light”RSC Adv., 4, 40120-40131.
  5. Banik, B.; Somyajit, K.; Nagaraju, G.; Chakravarty, A. R. (2014) “Oxovanadium(IV) complexes of curcumin for cellular imaging and mitochondria targeted photocytotoxicity” Dalton Trans., 43, 13359-13369.
  6. Banik, B.; Somyajit, K.; Hussain, A.; Nagaraju, G.; Chakravarty, A. R. (2014) “Carbohydrate-appended photocytotoxic (imidazophenanthroline)-oxovanadium(IV) complexes for cellular targeting and imaging” Dalton Trans., 43, 1321-1331.
  7. Hussain, A.; Somyajit, K.; Banik, B.; Banerjee, S.; Nagaraju, G.; Chakravarty, A. R. (2013) “Enhancing the photocytotoxic potential of curcumin on terpyridyllanthanide(III) complex formation” Dalton. Trans., 42, 182-195.
  8. Banik, B.; Somyajit, K.; Koley, D.; Nagaraju, G.; Chakravarty, A. R. (2012) “Cellular uptake and remarkable photocytotoxicity ofpyrenylterpyridineoxovanadium(IV) complexes of dipyridophenazine bases” Inorg. Chim. Acta, 393, 284-293.
  9. Balaji, B.; Banik, B.; Sasmal, P. K.; Maity, B.; Majumdar, R.; Dighe, R. R.; Chakravarty, A. R. (2012) “Ferrocene?Conjugated Oxidovanadium(IV) Complexes as Potent Near?IR Light Photocytotoxic Agents” Eur. J. Inorg. Chem., 126-135.
  10. Banerjee, S.; Hussain, A.; Prasad, P.; Khan, I.; Banik, B.; Kondaiah, P.; Chakravarty, A. R. (2012) “PhotocytotoxicOxidovanadium(IV) Complexes of Polypyridyl Ligands Showing DNA?Cleavage Activity in Near?IR Light” Eur. J. Inorg. Chem., 3899-3908.
  11. Banik, B.; Sasmal, P. K.; Roy, S.; Majumdar, R.; Dighe, R. R.; Chakravarty, A. R. (2011) “Terpyridineoxovanadium (IV) complexes of phenanthroline bases for cellular imaging and photocytotoxicity in HeLa cells” Eur. J. Inorg. Chem., 1425-1435.
  12. Balaji, B.; Somyajit, K.; Banik, B.; Nagaraju, G.; Chakravarty, A. R. (2013); “Photoactivated DNA cleavage and anticancer activity of oxovanadium(IV) complexes of curcumin” Inorg. Chim. Acta, 400, 142-150.
  13. Maity, B.; Roy, M.; Banik, B.; Majumdar, R.; Dighe, R. R.; Chakravarty, A. R. (2010) “Ferrocene-promoted photoactivated DNA cleavage and anticancer activity of terpyridylcopper(II) phenanthroline complexes” Organometallics, 84, 6907-6913.
  14. Lahiri, D.; Bhowmick, T.; Banik, B.; Railkar, R.; Ramkumar, S.; Dighe, R. R.; Chakravarty, A. R.(2010) “Photocytotoxic and anaerobic DNA cleavage activity of binuclear 3, 3′-dithiodipropionic acid cobalt(II) complexes having phenanthroline bases” Polyhedron, 29, 2417-2425.

Publication from Independent Research

  1. Sarma, N.; Baruah, S.; Malakar, A.; Chakrabortty, M.; Banik, B and Das, B. K. (2021) “Synthesis, Characterization and Antimicrobial Properties of [Cu2(μ-O2CC9H19)4(4-CNpy)2]”Asian J. Chem., 33(2), 453-458.
  2. Sheikh, N. S.;Banik, B. “CuPer-BSA-NPs: Copper Peroxide Nanodots Encapsulated in BSA Nanoparticles Exhibit Remarkable Tumor-Associated Macrophage Reprogramming Ability for Cancer Immunotherapy” Manuscript under preparation

Students

Sl.No Name Research Topic Roll No
1 Rupam Kumar Bora Platinum-based combination therapeutics CHM2291006
2 Debasish Sarma Platinum nanoparticles for anti-cancer therapeutics CHM2291009

Awards

  • DST INSPIRE Faculty Award from the Department of Science and Technology (DST), India, July 2017.
  • Early Career Investigators in Personalized Nanomedicine Research award from Society for Personalized NanoMedicine at the 3rd Annual Personalized Nanomedicine Conference held in Miami, May 19-20, 2016.
  • Travel Award from the ACS Division of Biological Chemistry to attend the 251st ACS National Meeting at San Diego, CA, U.S.A., March 13-17, 2016.

Patents

  • Marrache, S., Wen, R., Banik, B. and Dhar, S., “Nanoparticles for lipid homeostasis” US Patent Application No. US20170367989A1. Status: Patent Filed.
  • Kalathil, A. A., Banik, B., Kumar, A. and Dhar S., “Modification of drugs for incorporation into nanoparticles” US Patent Application No.US20170087167A1.Status: Patent Filed.

Other Informations

  • Member of American Chemical Society (2016 - 2021)
  • Served as reviewer for international peer-reviewed journals viz.:
    • ACS Nano
    • Inorganic Chemistry
    • ACS Omega
    • Chemical Communications
    • Dalton Transactions
    • New Journal of Chemistry
    • Chemistry-An Asian Journal
    • Chemistry Select
    • Chemistry and Biodiversity